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Sunday, July 19, 2020 | History

3 edition of Phospholipid-binding antibodies found in the catalog.

Phospholipid-binding antibodies

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  • 2 Currently reading

Published by CRC Press in Boca Raton .
Written in English

    Subjects:
  • Phospholipid antibodies.,
  • Antibodies -- immunology.,
  • Phospholipids -- immunology.

  • Edition Notes

    Includes bibliographical references and index.

    Statementeditors, E. Nigel Harris ... [et al.].
    ContributionsHarris, E. Nigel.
    Classifications
    LC ClassificationsQP752.P53 P46 1990
    The Physical Object
    Pagination435 p. :
    Number of Pages435
    ID Numbers
    Open LibraryOL1850871M
    ISBN 100849355362
    LC Control Number90002394

    Upregulation of the procoagulant activity of monocytes by antibodies to beta2-glycoprotein I (β2GPI) is one of the mechanisms contributing to thrombosis in antiphospholipid syndrome. Current knowledge about receptors responsible for the upregulation of procoagulant activity by β2GPI/anti-β2GPI complexes and their binding sites on β2GPI is far from by: 3. Anti-phospholipid (APL) antibodies are a heterogeneous group of autoantibodies targeting different phospholipid binding protein antigens. These autoantibodies include lupus anti-coagulant (LAC), anti-cardiolipin (aCL), anti-beta 2 glycoprotein 1 (anti-β 2 GP1), and anti-prothrombin antibodies [].APL antibodies dysregulate normal cellular activities and are associated with Cited by: 5.

    Ensembl ENSG ENSMUSG UniProt P P RefSeq (mRNA) NM_ NM_ NM_ NM_ NM_ RefSeq (protein) NP_ NP_ NP_ NP_ NP_ Location (UCSC) Chr – Mb Chr 2: – Mb PubMed search Wikidata View/Edit Human Aliases: PLTP, BPIFE, HDLCQ9, phospholipid . Peripheral membrane proteins are membrane proteins that adhere only temporarily to the biological membrane with which they are associated. These proteins attach to integral membrane proteins, or penetrate the peripheral regions of the lipid regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral .

      Also discussed is the clinical relevance of testing for antibodies to other phospholipids and phospholipid‐binding proteins when the lupus anticoagulant and anticardiolipin antibody tests are negative in patients with features of the APS, and those tests that are useful are : I. Giles. Looking for books by Graham R.V. Hughes? See all books authored by Graham R.V. Hughes, including Lupus: the Facts, and Talking About Lupus: What to Do and How to Cope, and more on


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Phospholipid-binding antibodies Download PDF EPUB FB2

First published in Historically, phospholipid binding antibodies were important in the study of syphilis. During the s there was a resurgence of new interest in these antibodies due to reported associations with recurrent Phospholipid-binding antibodies book, fetal loss, and other clinical disorders.

First published in Historically, phospholipid binding antibodies were important in the study of syphilis. During the s there was a resurgence of new interest in these antibodies due to reported associations with recurrent thrombosis, fetal.

Role of Monoclonal Antibodies in Understanding the Interactions Between Anti-Phospholipid Antibodies and Phospholipids (Joyce Rauch, Andrew S. Janoff). The Immunology of Phospholipid Binding Antibodies in the Anti-Phospholipid Syndrome and Related Disorders (E.

Nigel Harris, Genesio Balestrieri, Angela Tincani, Azzudin E. Gharavi). Phospholipid binding Antibodies.

Phospholipid-binding antibodies book for proteins involved in phospholipid binding pathways; according to their Panther/Gene Ontology Classification.

View more View less. Disclaimer. Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the. Sterling G. West, John G. Hanly, in Dubois' Lupus Erythematosus and Related Syndromes (Ninth Edition), Antiphospholipid Antibodies.

Antiphospholipid antibodies, directed against phospholipid-binding proteins such as β 2-GPI and prothrombin, induce a procoagulant state and are associated predominantly with focal manifestations of lupus anticoagulant.

These autoantibodies bind to β 2-glycoprotein I and other phospholipid-binding proteins, but the actual mechanism whereby they result in a hypercoagulable state remains uncertain.

Antiphospholipid antibodies are detected in the clinical laboratory by serological assays (anticardiolipin and anti-β 2 -glycoprotein-I antibodies) and coagulation. We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant.

Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL Cited by: Phospholipid-binding antibodies are now recognized as a risk factor for pregnancy loss in women with SLE and SLE-related disorders, but their importance is less clear in non-SLE women.

To improve our knowledge in this fascinating area we need to define the immunological targets of these antibodies. Antibodies for proteins involved in calcium-dependent phospholipid binding pathways, according to their Panther/Gene Ontology Classification.

Induction of phospholipid-binding antibodies in mice and rabbits by immunization with human beta 2 glycoprotein 1 or anticardiolipin antibodies alone. S S Pierangeli and E N Harris Department of Medicine, University of Louisville, KY Cited by:   Introduction.

The antiphospholipid (aPL) syndrome (APS) is a thrombophilic disorder that is defined by the presence of autoantibodies against phospholipid-binding cofactor proteins in patients with vascular thrombosis and/or pregnancy complications.

1 Of the various phospholipid-binding proteins, aPL antibody recognition of the phospholipid-binding protein, Cited by: Book 1 of 1: X-Men: Powerless | by Alan Davis, Terry Kavanagh, et al. | Sold by: Marvel Entertainment US.

out of 5 stars 3. Kindle Edition $ $ 6. 04 $ $ Buy now with 1-Click ® Phospholipid-Binding Antibodies (Routledge Revivals) by E. Nigel Harris, Thomas Exner, et al.

| Sold by: Services LLC. Kindle Edition. Reactivity profiles of autoantibodies to different phospholipids and the phospholipid-binding protein β2-glycoprotein I in patients with clinical symptoms related to thromboembolic and/or. Lupus anticoagulant activity of some antiphospholipid antibodies against phospholipid bound β2 glycoprotein I Article (PDF Available) in Journal of Clinical Pathology 46(7) August The antiphospholipid syndrome (APS) is caused by heterogeneous auto‐antibodies to various phospholipid‐binding proteins, and manifests in an increased risk of arterial and venous thrombosis or recurrent pregnancy by: 3.

Antiphospholipid antibodies are a group of immune proteins (antibodies) that the body mistakenly produces against itself in an autoimmune response to phospholipids. Tests can detect these autoantibodies that bind to phospholipids and, in a way that is not well understood, increase the risk of excessive blood clotting.

The present invention discloses a role of aminophospholipid and anionic phospholipids in tumor vasculature and the spread of viruses and surprising finding, as well as compositions and methods for treating cancer and found that these viral infections.

The present invention also discloses useful antibody may bind to and inhibit the aminophospholipid and anionic Cited by: APLA are primarily directed towards phospholipid binding proteins high rate of recurrent thrombosis in APS, especially in triple positive patients (patients with lupus anticoagulants, aCL and anti-ß2GPI antibodies), and indefinite anticoagulation with a vitamin K antagonist is the standard of care for thrombotic APS (2).

The antiphospholipid (aPL) syndrome (APS) is a thrombophilic disorder that is defined by the presence of autoantibodies against phospholipid-binding cofactor proteins in patients with vascular thrombosis and/or pregnancy complications. 1 Of the various phospholipid-binding proteins, aPL antibody recognition of the phospholipid-binding protein, β2-glycoprotein Cited by: The Garland Science website is no longer available to access and you have been automatically redirected to INSTRUCTORS.

All instructor resources (*see Exceptions) are now available on our Instructor instructor credentials will not grant access to the Hub, but existing and new users may request access student. Pierangeli SS, Harris EN () Induction of phospholipid binding antibodies in mice and rabbits by immunization with human β 2 glycoprotein 1 or anticardiolipin antibodies alone.

Clin Exp Immunol Google ScholarCited by:   INTRODUCTION. The vitamin K-dependent blood coagulation and regulatory proteins interact with phospholipid membranes in the presence of Ca 2+.This interaction plays an important biological role in the formation of protein complexes with enhanced catalytic properties (Furie and Furie, ).For instance, the catalytic activity (k cat /K m) of Factor IXa for the .The actual targets of “aPL” antibodies from patients with this autoimmune syndrome (in contrast to most patients who develop these antibodies in response to infection) are generally believed to be phospholipid-binding protein cofactors, the major one being the serum protein, β 2-glycoprotein I (β 2 GPI), also known as apolipoprotein H Cited by: